Nueva publicación del Grupo MICROBIO en la revista “Antioxidants” (Q1) de la editorial MDPI

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  • 26 septiembre 2022
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Artículo original que lleva por título: “Antioxidant, anti-Inflammatory, and antibacterial properties of an Achillea millefolium L. extract and its fractions obtained by supercritical anti-solvent fractionation against Helicobacter pyloriAntioxidants202211(10), 1849.

Publicado en la revista de acceso libre Antioxidants (Q1, Factor de Impacto 7.675) de la editorial MDPI, dentro del número especial “Advances in the astonishing world of phytochemicals: state-of-the-art for antioxidants” editado por la Dra. Antonella D’Anneo (Department of Sciences and Biological, University of Palermo, Italy) y la Dra. Marianna Lauricella (Department of Biomedicine, Neurosciences and Advanced Diagnostics, University of Palermo, Italy).

ABSTRACT: The main objective of this work is to evaluate the potential utility of an Achillea millefolium extract (yarrow extract, YE) in the control of H. pylori infection. The supercritical anti-solvent fractionation (SAF) process of YE allowed the obtaining of two different fractions: yarrow’s precipitated fraction (YPF), enriched in most polar phenolic compounds (luteolin-7-O-glucoside, luteolin, and 3,5-dicaffeoylquinic acid), and yarrow’s separator fraction (YSF), enriched in monoterpenes and sesquiterpenes, mainly containing camphor, artemisia ketone, and borneol. YE was effective in reducing reactive oxygen species (ROS) production in human gastric AGS cells by 16% to 29%, depending on the H. pylori strain. YPF had the highest inhibitory activity (38–40%) for ROS production. YE modulated the inflammatory response in AGS gastric cells, decreasing IL-8 production by 53% to 64%. This IL-8 inhibition also showed a strain-dependent character. YPF and YSF exhibited similar behavior, reducing IL-8 production, suggesting that both phenolic compounds and essential oils could contribute to IL-8 inhibition. YSF showed the highest antibacterial activity against H. pylori (6.3–7.1 log CFU reduction, depending on the strain) and lower MIC (0.08 mg/mL). Results obtained have shown that YE and SAF fractions (YPF and YSF) were effective as antioxidant, anti-inflammatory, and antibacterial agents regardless of the H. pylori strain characteristics.

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